Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Hyperglycemia is common among preterm and VLBW neonates. The most common causes include parentral administration of glucose, sepsis, stress, drugs and neonatal diabetes mellitus (DM). Hyperglycemia was associated with increased risk for death and morbidities e.g. intraventricular hemorrhage(IVH), infection, Retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). To determine adverse outcomes of hyperglycemia during the first week of life in preterm and VLBW neonates. Patients and methods: This prospective study included 100 preterm and VLBW neonates admitted in the neonatology unit of Kasr Alainy hospital. We reviewed the medical records during first week of life and grouped them according to peak blood glucose level in to group A (hyperglycemic cases) blood glucose > 120 mg / dL and group B (normoglycemic cases) blood glucose < 120 mg/dL. In our study males were more prevalent than females (54% versus 46%). Cesarean section as a mode of delivery was the majority with 74% to 26% who were delivered by vaginal delivery. Respiratory distress syndrome (72%), sepsis (26%), blood transfusion (94%), Mechanical ventilation (50%), Maternal preeclampsia (36%) are risk factors for development of hyperglycemia. The hyperglycemia is associated with increase development of sepsis (28%) and death (56%). Vi Hyperglycemia among preterm and VLBW neonates remain to be at needs to be properly followed up and managed as it is associated with increased morbidities and mortality among this high group

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