Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Aim of the work: In the current study, we aimed to illustrate features, epidemiology of acute immune thrombocytopenia (ITP) andestimate the prevalence and long-term outcome of acute ITP in our community. Also we aimed to compare the effect of different treatment regimens on the outcome and to estimate the percentage of chronicity and its predictive factors. Moreover, we aimed to establish a protocol of management and follow up guided by the results of our study.Subjects and methods: This is a 10 year observational retrospective study that included medical record reviewof 526 patients. All cases data collected included; name , sex, date of birth ,age at presentation, platelet count and bleeding symptoms , treatment received and response , complication(s) of disease ,and therapy (if they arise) including splenectomy. Patients' data in the first year of presentation were recorded including response to therapy and final outcome.Results: Among 526 patients there was 281 male and 245 female with (M: F) ratio 1.14:1, with a mean age 5 ± 3.2 years. Patients presented with skin bleeds in the form of purpura or ecchymosis in 349 patients (66.3%), mucous membrane bleeds as epistaxis or gum bleeding in 30 patients (5.7%) or both skin and mucous membrane bleeding in 137 patients (26%). The mean presenting platelet count was 18±17.6 x109/L. medical treatment was administered to 82.3% of patients with acute ITP but 17.7% did not receive any treatment. Seventy-three (13.8% of all patients) of those who received no treatment showed spontaneous remission

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