Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction: Childhood obesity is quickly becoming an important health problem worldwide. Obesity renal disease may be asymptomatic and difficult to be diagnosed, so useful biomarkers are necessary to prevent serious renal conditions in obese children.The soluble form of Kidney injury molecule-1 (KIM1) is easily detectable in urine and can be used as a renal marker of renal injury. Objective : The present study was conducted to estimate and evaluate KIM-1 as a biomarker for renal damage in obese children. Patients and methods: This cross-sectional study was carried on 120 obese children who were recruited from obesity clinic, Pediatric Hospital, Cairo University, in addition to 60 age and sex matched control group. All the included obese children were subjected to full history taking, examination, and investigations including urinary microalbumin, lipid profile, complete blood picture and KIM1 level in urine. Results: There is statistically significant difference as regards urinary KIM1 between obese cases and controls with P value =.001, Statistically significant difference between children with high KIM1 and children with normal KIM1 as regards urinary microalbumin and cholesterol level. KIM1 sensitivity is 87.5%, specificity 86.5% with P value<.001 as a marker of renal injury in obese children (KIM1. Cut off 2.55). Conclusion: Renal impairment is common in obese children and may have an early onset. Urinary KIM1 can be a good promising marker for early diagnosis of renal injury in obese children

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