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Prognostic Significance Of Determination Of Tumor Angiogenesis In Pediatric Solid Tumors /

Safinaz Adel ElHabashy

Prognostic Significance Of Determination Of Tumor Angiogenesis In Pediatric Solid Tumors / الاهمية التكهنية للتعرف على تكون الاوعية الدموية فى اورام الاطفال المصمتة Safinaz Adel ElHabashy ; Supervised Salah Saleh Abd El Hadi , Ahmed Samy Khalifa , Nader Abd El Latif Dahaba - Cairo : Safinaz Adel ElHabashy , 2005 - 156P : ill ; 30cm

Thesis (PH.D.) - Cairo University - National Cancer Institute - Department Of Pediatric Oncology

The current study was conducted aiming to define the role of angiogenesis in pediatric solid tumors , investigate the usefulness of VEGF as a possible prognostic factor in conjunction with the more established parameters , find out any relation between angiogenesis markers and disease stage , number of metastases and volume of involvement , and evaluate any predictive value of serum angiogenic markers on possibility of response to cytotoxic therapyDuring the period January 2000 till May 2004 , 51 patients with solid tumors were enrolledThey were registering to Pediatric Department of NCI (40 patients) , Cairo University , and Pediatric Hematology / Oncology Clinic (11 patients) , Ain Shams UniversityThey were 27 boys and 24 girls whose ages ranged between 2 and 168 monthsTwenty healthy children were recruited to determine normal concentration of serum vascular endothelial growth factor (VEGF) A verbal consent was obtained from legal guardians prior inclusion in study



Pediatric Solid Tumors Prognostic Significance Tumor Angiogenesis