header

Effect of some oxidative and antioxidative agents on nucleic acid damage and repair of rats /

Marwa Ibrahim Abdelhamid Ahmed

Effect of some oxidative and antioxidative agents on nucleic acid damage and repair of rats / تاثير بعض المواد المؤكسدة والمواد المضادة للاكسدة على اتلاف واعادة اصلاح الحامض النووى فى الفئران Marwa Ibrahim Abd El Hamid Ahmed ; supervised Hassan Abdelhaleem Hassan Amer , Magdy Ahmed Ghoneim , Adel Mohamed Abou ElFetouh - Cairo : Marwa Ibrahim Abdelhamid Ahmed , 2005 - 166P : ill ; 30cm

Thesis (M.Sc.) - Cairo University - Faculty Of Veterinary Medicine - Department Of Biochemistry and Chemistry Of Nutrition

Treatment of rats with a single dose of Cyclophosphamide and Benzo (a) Pyrene evoked the elevation of oxidative biomarkersThese oxidative agents caused marked elevation in the DNA fragmentation , raised the liver microsomal malondialdehyde level , caused mutation and increased the concentration of 8 - OHdGSupplementation of rats with Curcumin and chlorophyllin , as antioxidants , before and after the oxidants treatment , reduced these oxidative biomarkersThese antioxidants were proved to be potent in protecting rats against the oxidative stress induced by Cyclophosphamide and Benzo (a) Pyrene



Damage and repair Nucleic acid Oxidative and antioxidative Rats