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Evaluation of platelet-rich fibrin/ biphasic calcium phosphate effect versus autogenous bone graft on reconstruction of alveolar cleft defect in the maxillary arch : randomized controlled clinical trial /

Hebat-Allah Gomaa Samra Samra El-Shamy,

Evaluation of platelet-rich fibrin/ biphasic calcium phosphate effect versus autogenous bone graft on reconstruction of alveolar cleft defect in the maxillary arch : randomized controlled clinical trial / : تقييم تأثير الفيبرين الغنى بالصفائح الدموية ممزوجا بفوسفات الكالسيوم ثنائى الطور مقابل رقعة عظم ذاتى على اعادة بناء الشق السنخى / تجربة اكلينيكية عشوائية by Hebat-Allah Gomaa Samra Samra El-Shamy ; Supervisors Prof. Dr. Hamida Refaii, Prof. Dr. Hassan Abdel-Ghany Othman. - 95 pages : illustrations ; 25 cm. + CD.

Thesis (Ph.D)-Cairo University, 2023.

Bibliography: pages 82-93.

Aim: The purpose of this study was to evaluate the efficiency of platelet-rich fibrin combined biphasic calcium phosphate usage in repairing of alveolar cleft defect and compare its efficacy with that of autogenous bone by means of volumetric analysis.
Patients and methods: controlled clinical trial including 18 patients with alveolar cleft defect. a control group grafted with corticocancellous bone graft harvested from the anterior iliac crest and study group grafted with platelet-rich fibrin combined biphasic calcium phosphate. Cone beam computed tomography were obtained 1 week preoperatively,2 weeks and 6 months postoperatively to assess the Preoperative volume of alveolar cleft defect, volume of packed graft material, the volume of newly formed bone and the height of bone bridge 6 months postoperatively.
Results: The control group had significant larger volume of bone bridging compared with the study group.
Conclusion: Autogenous bone still the first choice for alveolar cleft grafting





Text in English and abstract in Arabic & English.


Oral Surgery

alveolar cleft cleft lip and palate reconstruction bone grafting platelet concentrate PRF platelet-rich fibrin growth factors

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