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Cancer epigenetics from basic biology to molecular targeted therapy /

Abdallah Mohamed Gamil Abdallah

Cancer epigenetics from basic biology to molecular targeted therapy / ما حول العوامل الجينية للسرطان من الاسس الحيوية الى العلاجات الجزيئية الاستهدافية Abdallah Mohamed Gamil Abdallah ; Superivsed Iman Maher Mansour , Gamal Thabet Ali Ebid - Cairo : Abdallah Mohamed Gamil Abdallah , 2009 - 182P. : facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence . DNA methylation and histone modification ( methylation acetylation deacetation and phosphorylation ) are epigenetic mechanisms which regulate gene expression . DNA methylation down- regulates gene activity while modification of the histone can be carried out multiple mechanisms leading to either the upregulation or down- regulation of the associated gene



Cancer epigenetics DNA methylation Histone modification bisulfite modification