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Nucleophosmin gene mutation in de novo acute myeloid leukaemia /

Marwa Salah Farhan

Nucleophosmin gene mutation in de novo acute myeloid leukaemia / اهمية طفرة جين النيوكليوفوزمين فى حالات سرطان الدم الميلودى الحاد Marwa Salah Farhan ; Supervised Aisha Mostafa Abdelrahman , Eman Refaat Elmahgoub , Nesren Mohamed Elgharbawy - Cairo : Marwa Salah Farhan , 2009 - 151 P. : charts , facsimiles ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Somatic mutation nucleophosmin gene (NPMI) has been reported in acute myeloid leukaemia (AML) . In the present study , NPMI mutation was investigated by reverse trascriptase - PCR (RT-PCR) in 27 patients with de novo AML as well as 10 normal subjects as a control group . Internal tandem duplication mutation of Fms- like tyrosine kinase 3 (FLT3/ITD) and length mutation of FLT3 (FLT3/LM) were also analyzed



Acute myeloid leukaemia Gene mutation Nucleophosmin