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Study of the encapsulation of the antitubercular pyrazinamide in niosomes /

Sameh Hosam Eldin Abdelalim

Study of the encapsulation of the antitubercular pyrazinamide in niosomes / دراسة لحوصلة مضاد الدرن البيرازيناميد داخل نيوزومات Sameh Hosam Eldin Abdelalim ; Supervised Ahmed Abdelbary Abdelrahman , Mohammed Shafik Elridy - Cairo : Sameh Hosam Eldin Abdelalim , 2010 - 234P. : charts , facsimiles; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The work in this thesis involves formulation and characterization of pyrazinamide niosomal formulations aiming to increase the efficacy decrease the drug side effects and toxicity . Pyrazinamide niosomal were formulated using Span 60 and Span 85 along with cholsterol and charge inducing agents . Different factors affecting the entrapment of pyrazinamide in the perpared niosomes were studied including the effect of molar ratio surface chang and swelling time



Niosomes Pyrazinamide Tuberculosis