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The association of k121Q polymorphism of the plasma cell membrane glycoprotein - 1 gene with type 2 diabetes mellitus /

Amaal Abdou Abdelaal

The association of k121Q polymorphism of the plasma cell membrane glycoprotein - 1 gene with type 2 diabetes mellitus / التعددات الشكلية لجين غشاء خلية البلازما جليكوبروتين ك 121 كيو ومصاحبته لمرض البول السكرى نوع 2 Amaal Abdou Abdelaal ; Supervised Ola Abdelmoneim Elsisy , Amal Abdelwahab Mohamed , Rokaya Abdelaziz Mohamed - Cairo : Amaal Abdou Abdelaal , 2008 - 126P. : charts ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Insulin resistance is a key factor in the etiology of type 2 diabetes mellitus . Genes involved in insulin resistance are therefore likely to affect susceptibility to these diseases . One such gene PC - 1 encodes plasma cell glycoprotein - 1 which may play an essential role in insulin resistance by inhibiting insulin receptor signaling through interaction with the Ü subunit



Genotype PC - 1 K121Q Type 2 Diabetes