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Assessment of the role of lipoic acid in modulating the genotoxic effects of copper sulphate in mice /

Marwa Ahmed Naguib Mohamed

Assessment of the role of lipoic acid in modulating the genotoxic effects of copper sulphate in mice / تقييم مدى فاعلية حمض الليبويك فى معادلة الأثر السمى الوراثى لكبريتات النحاس فى الفأر Marwa Ahmed Naguib Mohamed ; Supervised Mahmoud Ahmed M. Amer , Amany A. Tohamy , Magda Mohamed Noshy - Cairo : Marwa Ahmed Naguib Mohamed , 2010 - 106Leaves : charts , facsimiles ; 30cm

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

The assumption of oxidative stress as a mechanism in copper toxicity suggests that antioxidants might play a role in the treatment of copper poisoning . The present study was designed to evaluate the efficacy of alphalipoic acid ( LA ) protection against chromosomal damage induced by copper sulphate in bone marrow cells of mice using two cytogenetic end points, chromosomal aberrations analysis ( CAs ) and micronucleus ( MN ) test



Chromosomal aberrations Copper sulphate Lipoic acid