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Immunohistochemical expression of matrix metalloproteinase mmp - 9 in chronic and aggressive periodontitis /

Ahmed Mohamed Hossam Eldin Abdelaziz

Immunohistochemical expression of matrix metalloproteinase mmp - 9 in chronic and aggressive periodontitis / بيان المناعة الهيستوكيميائية لوجود انزيم البروتين المعدنى - 9فى التهاب النسيج السنى المزمن والمتقدم Ahmed Mohamed Hossam Eldin Abd El aziz ; Supervised Reda Abd El Rahman , Azza Ezz ElArab - Cairo : Ahmed Mohamed Hossam Eldin Abdelaziz , 2006 - 11P : ill ; 30cm

Thesis (M.Sc.) - Cairo University - Faculty Of Oral and Dental Medicine - Department Of Periodontology

All components of ECM are degraded by matrix metalloproteinases (MMPs) , a family of zinc - dependent neutral endopeptidases (Birkedal - Hansen et al , 1993) Two types of MMPs are required for dissolution of interstitial collagen : collagenases and gelatinases (Mao D et al , 1999) Collagenase - 1 (MMP - 1) , collagenase - 2 (MMP - 8) and collagenase - 3 (MMP - 13) are the principal secreted neutral proteinases that initiate degradation of native fibrillar collagens of type I , II , III and VThey all cleave fibrillar collagens , which are further degraded by gelatinases (Kahari and Saarialho - Kere , 1999)



Matrix metalloproteinase MMP - 9