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Design of non-atp competitive inhibitors of polo-like kinases through "Replace" /

Doaa Boshra Abdulfattah Farag

Design of non-atp competitive inhibitors of polo-like kinases through "Replace" / تصميم مثبطات غير تنافسية للأدينوزين ثلاثي الفوسفات لبعض البولو كيناز بإستخدام طريقة "إستبدال" Doaa Boshra Abdulfattah Farag ; Supervised Ashraf Mostafs K. H. Abadi , Amal Abdelhaleem M. Eissa - Cairo : Doaa Boshra Abdulfattah Farag , 2010 - 126 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Application of REPLACE technique to develop peptide-small molecule hybrids as polo-box domain inhibitors, using computational chemistry methods with discovery studio 2.1 software, 14 structures were synthesized by solid phase synthesis using Fmoc methodology, and purification techniques with HPFC and HPLC methods



Anti-tumor Polo-box domain Protein kinase inhibitors