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In vitro stimulation of hemoglobin F production in thalassemic patients by the histone deacetylase inhibitor apicidin /

Jowiria Aboelela Said

In vitro stimulation of hemoglobin F production in thalassemic patients by the histone deacetylase inhibitor apicidin / تحفيز دوالى خارجى جديد للهيموجلوبين اف فى حالات أنيميا البحر الأبيض المتوسط Jowiria Aboelela Said ; Supervised Nesrine Mohamed Elgharbawi , Iman Abdelmohsen Abdushaheen - Cairo : Jowiria Aboelela Said , 2010 - 135P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Pharmacologic stimulation of fetal hemoglobin (HbF) expression may be a promising approach for treatment of Ý - thalassemia . The aim of the present study was to determine the effect of a histone deacetylase inhibitor Apicidin on HbF production in Ý - thalassemic - cultured erythroid precursor cells . The study was conducted on twenty five Ý - thalassemic patients



HbF Histone deacetylase inhibitor Ý - thalassemia