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The cardioprotective role of carvedilol and selenium against doxorubicin - induced cardiotoxicity in rats /

Heba Tullah Samy Muhammad Helmy

The cardioprotective role of carvedilol and selenium against doxorubicin - induced cardiotoxicity in rats / دور عقارى الكارفيديلول والسيلينيوم فى حماية القلب من الأثر الضار لعقار الدوكسوروبيسين فى الجرذان Heba Tullah Samy Muhammad Helmy ; Supervised Maged A. Barakat , Safinaz S. Ibrahim - Cairo : Heba Tullah Samy Muhammad Helmy , 2010 - 157P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

The present study was performed to investigate the effect of dixorubicin chronic administration on certain biochemical parameters in heart of rats in addition to the histopathological study of cardiac and hepatic tissues. It was, also, extended to explore the role of pre - administration of antioxidants such as carvedilol and selenium in ameliorating doxorubicin cardiomyopathy . In this study these protective agents were administered either separately or in combination using half dose of carvedilol



Carvedilol Doxorubicin Selenium