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Induction of selected deletion in HA gene of Egyptian HPAI - H5N1 viruses using site directed mutagenesis /

Nahed Yehia Abdelaziz

Induction of selected deletion in HA gene of Egyptian HPAI - H5N1 viruses using site directed mutagenesis / تطبيقات على التطفر الموجه لاحداث ازالة فى جين التلزن الدموى لفيروسات انفلونزا الطيور سلالة( H5N1) شديدة الضراوة Nahed Yehia Abdelaziz ; Supervised Mohamed Abdelhameed Shalaby , Ismail Mohamed Reda , Abdelsatar Arafa - Cairo : Nahed Yehia Abdelaziz , 2011 - 163 Leaves : charts , facsimiles ; 30cm

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Virology

HA is a critical determinant of the pathogenicity of avian influenza viruses . The HA proteins of highly pathogenic H5 and H7 viruses contain multiple basic amino acids at the cleavage site that are recognized by ubiquitous proteases but low patgogenic virus contain a single arginine resdue at the HA cleavage site that are recognized by trypsin - like protease found generally at epithelial cell surfaces



HACS HPAI 8LPAI SDM