Methylation framework of cell cycle gene inhibitor p16 INK4A in hepatocellular carcinoma patients /
Hany Ahmed Fouad Elghobary
Methylation framework of cell cycle gene inhibitor p16 INK4A in hepatocellular carcinoma patients / فى مرضى سرطان الخلايا الكبدية p16INK4A ميثلة الجين المثبط للدورة الخلوية جين ال Hany Ahmed Fouad Elghobary ; Supervised Fatma Ahmed Elmougy , Nabil Mostafa Khalil Elkady , Sahar Abdelatty Sharaf - Cairo : Hany Ahmed Fouad Elghobary , 2012 - 168P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Hepatocellular carcinoma ( HCC ) is currently the fifth most common solid tumor worldwide and the third leading cause of cancer related death . The tumor suppressor gene p16 INK4A is located on chromosome 9p21 and encodes the p16 protein , which binds selectively to CDK4 to inhibit activation of the CDK4 / cyclin D complex in the G1 phase . Inactivation of this gene which normally inhibits progression to the G1 phase of the cell cycle is involved in the initiation of tumors
Cell cycle gene Hepatocellular p16 INK4A
Methylation framework of cell cycle gene inhibitor p16 INK4A in hepatocellular carcinoma patients / فى مرضى سرطان الخلايا الكبدية p16INK4A ميثلة الجين المثبط للدورة الخلوية جين ال Hany Ahmed Fouad Elghobary ; Supervised Fatma Ahmed Elmougy , Nabil Mostafa Khalil Elkady , Sahar Abdelatty Sharaf - Cairo : Hany Ahmed Fouad Elghobary , 2012 - 168P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Hepatocellular carcinoma ( HCC ) is currently the fifth most common solid tumor worldwide and the third leading cause of cancer related death . The tumor suppressor gene p16 INK4A is located on chromosome 9p21 and encodes the p16 protein , which binds selectively to CDK4 to inhibit activation of the CDK4 / cyclin D complex in the G1 phase . Inactivation of this gene which normally inhibits progression to the G1 phase of the cell cycle is involved in the initiation of tumors
Cell cycle gene Hepatocellular p16 INK4A