Real - time PCR assay of VKORC1 and CYP2C9 gene polymorphisms that affect warfarin response /
Sherif Mofeed Megalla Ekladious
Real - time PCR assay of VKORC1 and CYP2C9 gene polymorphisms that affect warfarin response / استخدام تفاعل البلمرة المتسلسل فى الزمن الحقيقى لاكتشاف الأشكال الجينية للجين CYP2C9والجينVKORC1 اللذان يؤثران على الاستجابة لدواء الوارفارين Sherif Mofeed Megalla Ekladious ; Supervised Hazem Elsayed Abouyoussef , Sahar Abdelatty Sharaf , Marianne Samir Makboul - Cairo : Sherif Mofeed Megalla Ekladious , 2012 - 127P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Warfarin is a commonly used oral anticoagulant with a narrow therapeutic index and various genetic and clinical factors that influence interpatient variability in dose requirements . This study investigated the impact of genetic and nongenetic factors on warfarin dose requirements in Egyptians . DNA was extracted from 50 patients taking warfarin for more than 1 year and genotyped for VKORC1 (1173 C> T) , CYP2C9 *3 (1075 C>)gene polymorphisms using SYBR Green - based multiplex allele - specific PCR
CYP2C9 VKORC1 Warfarin
Real - time PCR assay of VKORC1 and CYP2C9 gene polymorphisms that affect warfarin response / استخدام تفاعل البلمرة المتسلسل فى الزمن الحقيقى لاكتشاف الأشكال الجينية للجين CYP2C9والجينVKORC1 اللذان يؤثران على الاستجابة لدواء الوارفارين Sherif Mofeed Megalla Ekladious ; Supervised Hazem Elsayed Abouyoussef , Sahar Abdelatty Sharaf , Marianne Samir Makboul - Cairo : Sherif Mofeed Megalla Ekladious , 2012 - 127P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Warfarin is a commonly used oral anticoagulant with a narrow therapeutic index and various genetic and clinical factors that influence interpatient variability in dose requirements . This study investigated the impact of genetic and nongenetic factors on warfarin dose requirements in Egyptians . DNA was extracted from 50 patients taking warfarin for more than 1 year and genotyped for VKORC1 (1173 C> T) , CYP2C9 *3 (1075 C>)gene polymorphisms using SYBR Green - based multiplex allele - specific PCR
CYP2C9 VKORC1 Warfarin