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Role of MCP-1 and its receptor CCR2 gene polymorphisms in the susceptibility to hepatocellular carcinoma /

Hanan Shawky Amin

Role of MCP-1 and its receptor CCR2 gene polymorphisms in the susceptibility to hepatocellular carcinoma / دور المضادات الجينية إم سي بي-١و مستقبله سي سي آر ٢ في قابلية حدوث سرطان الكبد Hanan Shawky Amin ; Supervised Lamiaa Ali Mansour , Laila Nessim Kamel , Marwa Abdelbadie Sheta - Cairo : Hanan Shawky Amin , 2012 - 118 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

MCP-1 is a member of the CC class of the beta chemokine family and one the key factors involved in the initiation of inflammation secreted by fibroblasts, endothelial cells, vascular smooth muscle cells, monocytes, T cells, and other cell types that mediate the influx of cells to sites of inflammation. It exerts its effect through binding to G-protein coupled receptors (CCR2) which is expressed on monocytes\ macrophages and on a subpopulation of T lymphocytes



CCR2 HCV and hepatocellular carcinoma MCP-1