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Formulation and biopharmaceutical evaluation of anti-acne drug in a pharmaceutical form /

Mayada Elhadi Babiker Ahmed

Formulation and biopharmaceutical evaluation of anti-acne drug in a pharmaceutical form / دراسة بايوصيدلية على عقار مضاد لحب الشباب Mayada Elhadi Babiker Ahmed ; Supervised Mahmoud Mohamed Ghorab - Cairo : Mayada Elhadi Babiker Ahmed , 2012 - 134 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

Isotretinoin (13-cis-retinoic acid) is a poor water- soluble drugs commonly used in the treatment of severe cases of acne. The aim of this project is formulate isotretinoin in form of tablet and enhance its solubility and dissolution rate by the use of formulations containing either surfactant (SlS and Tweeen 20) or HP-Ý-CD.The critical micelle concentration for each surfactant was determined



HP-Ý-CD Isotretinoin Surfactant enriched tablets