Design and synthesis of novel Ý - carboline derivatives as phosphodiesterase 5 inhibitors and anticancer agents /
Nancy Maher Riad Girgis
Design and synthesis of novel Ý - carboline derivatives as phosphodiesterase 5 inhibitors and anticancer agents / تصميم وتشييد مشتقات جديدة من البيتا كاربولين مثبطات لإنزيم فوسفودايستراز 5 ومضادات للسرطان Nancy Maher Riad Girgis ; Supervised Ashraf H. Abadi - Cairo : Nancy Maher Riad Girgis , 2010 - 138Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry
Tadalfil is one of the widely marketed medications for the treatment of male erectile dysfunction . Despite its potency and efficacy it is still not free from side effects and its cross reactivity with other phosphodiesterases particularly PDE11 is still a point of question . Moreover many recent studies have showed that PDE5 and other PDEs are over - expressed in malignant tumor cells thus inhibiting PDEs action may be related to anticancer and apoptotic activities
Design and synthesis of novel Ý - carboline derivatives as phosphodiesterase 5 inhibitors and anticancer agents / تصميم وتشييد مشتقات جديدة من البيتا كاربولين مثبطات لإنزيم فوسفودايستراز 5 ومضادات للسرطان Nancy Maher Riad Girgis ; Supervised Ashraf H. Abadi - Cairo : Nancy Maher Riad Girgis , 2010 - 138Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical chemistry
Tadalfil is one of the widely marketed medications for the treatment of male erectile dysfunction . Despite its potency and efficacy it is still not free from side effects and its cross reactivity with other phosphodiesterases particularly PDE11 is still a point of question . Moreover many recent studies have showed that PDE5 and other PDEs are over - expressed in malignant tumor cells thus inhibiting PDEs action may be related to anticancer and apoptotic activities