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Isolation, purification and biological evaluation of sarcophine and one of its semisynthetic derivatives from the Red Sea soft coral Sarcophyton glaucum /

Hesham Adel Saleh

Isolation, purification and biological evaluation of sarcophine and one of its semisynthetic derivatives from the Red Sea soft coral Sarcophyton glaucum / Hesham Adel Saleh ; Supervised Nazih Noureldin , Hans-Georg Breitinger - Cairo : Hesham Adel Saleh , 2010 - 98Leaves : charts ; 30cm

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Sarcophine is an epoxy cembranolide isolated in good yields from the Red Sea soft coral Sarcophyton glaucum showing various biological activities ; most prominent are its anticancer effects . However since the molecule is primarily a defense toxin for its coral ; utilizing this lead compound for pharmacological use is conditioned by its toxicity profile that would hinder introducing it for clinical trials if not safe levels