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Application of biodegradable nanopartieles in liver targeting of tacrolimus /

Salma Nabil Tammam

Application of biodegradable nanopartieles in liver targeting of tacrolimus / Salma Nabil Tammam ; Supervised Nagia Nagib Afifi , Ola Heikal - Cairo : Salma Nabil Tammam , 2010 - 163 Leaves : charts , facsimiles ; 30cm

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Technology

Tacrolimus is a potent immunosuppressant used in liver transplantation to avoid graft rejection. Tacrolimus has a narrow therapeutic index and exhibits variable phamacokinetics with high inter and intra-patient variability making dose adjustment and therapeutic drug monitoring a complicated task, not to mention increasing the occurrence of adverse effects