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A pharmaceutical study on zaleplon /

Ibtehal Salah Addin Abdulsaboor Ahmad

A pharmaceutical study on zaleplon / دراسة صيدلية على عقار الزاليبلون Ibtehal Salah Addin Abdulsaboor Ahmad ; Supervised Ahmed Abdelbary , Omaima N. Elgazayerly , Arwa Elhagrasy - Cairo : Ibtehal Salah Addin Abdulsaboor Ahmad , 2013 - 238P. : charts , facsimiles ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy- Department of Pharmaceutics

Zaleplon is a hypnotic drug used for the treatment of insomnia . It has elimination half life of 1 hour . But , it suffers from low bioavailability following oral administration using traditional dosage forms due its poor solubility and its extensive first pass metabolism . It needs to be incorporated into a dosage form that enhances its bioavailability and also be in a dosage form which sustains the release of the drug for duration of time enough to maintain sleep



Microparticles Orally disintegrating tablets Zaleplon