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Immunologic and genetic response to occupationally cisplatin- induced DNA adducts /

Rehab Shehata Abdelhady Shehata

Immunologic and genetic response to occupationally cisplatin- induced DNA adducts / الاستجابة المناعية والوراثية لمركبات الحمض النووى مع السيسبلاتين الناجمة عن التعرض لها مهنيا Rehab Shehata Abdelhady Shehata ; Supervised Gamal H. Elsamra , Inas M. Fawzy Gaballah , Laila Ahmed Rashed - Cairo : Rehab Shehata Abdelhady Shehata , 2013 - 158 P. : charts , facsimiles ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Industrial and Occupational Disease

Despite considering cisplatin as one of the most efficient antineoplastic druges it has been classified as group 2 A probably carcinogenic to humans . Its toxicity is executed through DNA damage ending in cell death or mutation . Objectives : This study aims at evaluation of the hazardous health effects of cisplatin exposure among healthcare workers at the oncology department Kasr Elaini hospital by assessing DNA damage repair and immune response to that damage among those exposed workers



Cisplatin Cisplatin DNA adducts Rad 52