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Role of basic fibroblast growth factor in suppressing senescence of human bone marrow- derived mesenchymal stem cells /

Nourhan Mohamed Diaa Eldien Abushahba

Role of basic fibroblast growth factor in suppressing senescence of human bone marrow- derived mesenchymal stem cells / دور عامل نمو الفايبروبلاست الأساسى فى تثبيط شيخوخة الخلايا الجذعية المزنكيمية المستمدة من نخاع العظم البشرى Nourhan Mohamed Diaa Eldien Abushahba ; Supervised Magda M. Noshy , Alice K. Abdelaleem - Cairo : Nourhan Mohamed Diaa Eldien Abushahba , 2012 - 144 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

Mesenchymal stem cells (MSCs) have a limited lifespan in vitro . After a definite number of cell divisions MSCs enter a senescence phase where they undergo cell growth arrest and can be no longer used in therapeutic applications . Basic fibroblast growth factor (bFGF) is a growth factor that has the capability to maintain MSCs cells in an immature state and enhances their growth during in vitro expansion



Basic fibroblast growth factor Bone marrow- derived MSCs Cellular senescence