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Synthesis, reactions and biological activities of some perimidine derivatives /

Huda Kamel Mahmoud

Synthesis, reactions and biological activities of some perimidine derivatives / تشييد و تفاعلات و النشاط البيولوجى لبعض مشتقات البريميدين Huda Kamel Mahmoud ; Supervised Thoraya Abdelreheem Farghaly - Cairo : Huda Kamel Mahmoud , 2013 - 141 P. ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry

The original work of the submitted thesis consists of two new research projects entitled: (1) Site- and regioselectivity of the reaction of hydrazonoyl Chlorides with perimidine-ketene animal. Antimicrobial evaluation of the products and (2) Synthesis, Tautomeric structures and antitumor activity of new perimidines. In the first project: reaction of hydrazonoyl chlorides with perimisine ketene amimal derivative in dioxane in the presence of triethylamine afforded either pyrrolo[1,2-Ü]perimidines or pyrazolyl perimidines depending on the type of hydrazonoyl chloride used



Hydrazonoyl halide Perimidine Regioselectivity