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A trial to investigative the effect of MSC's on regulatory T-Cell /

Salma Mohamed Said Ali Amin

A trial to investigative the effect of MSC's on regulatory T-Cell / محاولة لدراسة تأثير الخلايا الجذعية على الخلايا الليمفاوية المنظمة تى Salma Mohamed Said Ali Amin ; Supervised Azza Mostafa Ibrahim , Heba Nabil Abdelrazik , Doha Abdelhamid Mokhtar - Cairo : Salma Mohamed Said Ali Amin , 2013 - 156 P. : charts , facsimiles ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Mesenchymal stem cells (MSCs) are adult, multipotent, stem cells with immunomodulatory properties. One of the mechanisms used by MSCs to perform such action is its ability to increase the number of CD4+CD25+FOXP3+Tregs invitro. In the present work we tried to investigate the capacity of BM-MSCs to increase the number of Treg cells after co-culturing with PBMNCS from SLE and normal subjects under appropriate culture condition



Mesenchymal stem cells SLE T-regulatory cells