Synthesis and pharmacological evaluation of novel N - acyl (phenylpropylamine) analogs as MT₂⁻ selective ligands for melatonin receptors /
Norhan Samir Mahfouz
Synthesis and pharmacological evaluation of novel N - acyl (phenylpropylamine) analogs as MT₂⁻ selective ligands for melatonin receptors / Norhan Samir Mahfouz ; Supervised Darius P. Zlotos - Cairo : Norhan Samir Mahfouz , 2012 - 125 Leaves ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Pharmacological actions of the neurohormone melatonin are mediated by the activation of the two G - protein coupled receptors MT₁ and MT₂. An accurate characterisation of melatonin receptor - mediated functions requires MT₁ and MT₂⁻ selective ligands while pronounced MT₁ selectivity is still a challenge, many MT₂⁻ selective ligands, exemplified by compound 14c, have been reported, most of them behaving as antagonists
Synthesis and pharmacological evaluation of novel N - acyl (phenylpropylamine) analogs as MT₂⁻ selective ligands for melatonin receptors / Norhan Samir Mahfouz ; Supervised Darius P. Zlotos - Cairo : Norhan Samir Mahfouz , 2012 - 125 Leaves ; 30cm
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Pharmacological actions of the neurohormone melatonin are mediated by the activation of the two G - protein coupled receptors MT₁ and MT₂. An accurate characterisation of melatonin receptor - mediated functions requires MT₁ and MT₂⁻ selective ligands while pronounced MT₁ selectivity is still a challenge, many MT₂⁻ selective ligands, exemplified by compound 14c, have been reported, most of them behaving as antagonists