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Effect of human umbilical cord mesenchymal stem cells on breast carcinoma therapy /

Abeer Mostafa Ali Soliman

Effect of human umbilical cord mesenchymal stem cells on breast carcinoma therapy / استخدام الخلايا الجذعية المستخلصة من الحبل السرى للانسان فى علاج سرطان الثدى Abeer Mostafa Ali Soliman ; Supervised Mohamed Talaat Abdelaziz , Dina Sabry Abdelfatah , Ayman Ahmed Hassan - Cairo : Abeer Mostafa Ali Soliman , 2014 - 156 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry

Breast cancer is the most common malignancy in women, accounting for 27% of all female cancers; it accounts for < 1% of all cancer cases in men. Breast cancer also is responsible for 15% of cancer deaths in women, making it the number-two cause of cancer death. Human umbilical cord-derived mesenchymal stem cells (HUC - MSCs), isolated from discarded extra-embryonic tissue after birth, are promising candidate source of mesenchymal stem cells (MSCs). Apart from their advantages in abundant supply, painless collection, and faster self - renewal, HUC - MSCs have shown the potencies to differentiate into a variety of cells of three germ layer; HUC - MSCs synthesize and secret a set of trophic factors and cytokines to migrate toward inflammatory tissues such as cancer tissues



Breast carcinoma Doxorubicin Wharton jelly hMSCs