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The possible prophylactic role of vitamin E on methylprednisolone acetate - induced femoral head necrosis /

Asmaa Wageh Tahef

The possible prophylactic role of vitamin E on methylprednisolone acetate - induced femoral head necrosis / الدور الوقائى المحتمل لفيتامين هـ على تأكل رأس عظم الفخذ المستحث بالميثيل بريدنيزيلون اسيتيت Asmaa Wageh Tahef ; Supervised Nabila Yousef Abdelhalim , Safwat Wadie Gerges , Maha Khaled Abdelwahed - Cairo : Asmaa Wageh Tahef , 2014 - 96 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy

Corticosteroid is a risk factor inducing femoral head osteonecrosis. The antioxidant vitamin E could reduce such osteonecrosis. Sixty adult male albino rats were grouped into: GЇ (normal control), GII (sham control), GIII - MPSL subdivided into: (III - A - 3 days) and (III - B - 3 weeks), GIV (MPSL and vitamin E) subdivided into; (IV - A - 3 days) and (IV - B - 3 weeks). GIII showed femoral head cortical and medullary pleopathological changes, which were reduced in GIV after vitamin E adminstration, being more in subgroup IV - B than IV - A demonstrating a duration dependency



Femoral head Methylprednisolone acetate Osteonecrosis