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A comparative study on the healing potential of rabbit tibial defects treated with nanograft and freeze-dried bone allograft /

Sarah Mahmoud Abdelaal

A comparative study on the healing potential of rabbit tibial defects treated with nanograft and freeze-dried bone allograft / دراسة مقارنة على الشفاء المرتقب فى عيوب قصبة عظم ساق الأرنب المعالج بطعم النانو و طعم العظم الخيفى المجفف بالتجميد Sarah Mahmoud Abdelaal ; Supervised Bassant Adel Ezzat , Maha Hassan Bashir , Marwa Magdy Saad Abbas - Cairo : Sarah Mahmoud Abdelaal , 2014 - 144 Leaves : charts , facsimiles ; 30cm

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology

Objective: The aim of the study was to compare the bone healing potential of NanoBone (a synthetic bone graft material produced by nano-technology) versus MinerOss (a freeze dried bone allograft) in a rabbit tibial defect model. Materials and methods: Thirty adult male New Zealand white rabbits were used in this study. Two holes 1 cm apart 3.5 mm in diameter were created in each tibia reaching the bone marrow. The NanoBone was packed in the upper holes of the right side tibiae while the MinerOss was packed in the upper holes of the left side tibiae. The lower holes of the right and left tibiae were left untreated without any grafting material and acted as controls. The rabbits were randomly assigned into three groups I, II & III (10 rabbits each) according to the date of sacrifice 2, 4 and 6 weeks respectively. The specimens were then examined histologically, histomorphometrically and densitometrically using Dual Energy X-ray Absorptiometry (DEXA) scan



Allograft bone defects Nanograft