Association between MMP-9, MMP-3 polymorphisms and risk of myocardial infarction /
Baher Emil Ibrahim
Association between MMP-9, MMP-3 polymorphisms and risk of myocardial infarction / دراسة الرابطة بين الأشكال المتعددة من مصفوفة ميتالوبروتينيس و و خطر احتشاء عضلة القلب في المرضى المصريين Baher Emil Ibrahim ; Supervised Manal Michel Wilson , Ashraf Wadie Andraos , Nadia Ibrahim Swelem - Cairo : Baher Emil Ibrahim , 2014 - 94 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Myocardial infarction is caused by several inherited and acquired risk factors that predispose to the development of atherosclerotic lesions and plaque rupture.This rupture of an atherosclerotic plaque is a major event in the pathogenesis of an acute myocardial infarction (AMI). MMP-9 (gelatinase B) might play an important role in matrix degradation and the subsequent rupture of the atherosclerotic plaques. A functional single nucleotide polymorphism in the MMP-9 promoter, with a cytosine to thymidine transition at position -1562, was found. The T allele had a higher promoter activity than the C allele, and was associated with an elevation in both the levels of MMP-9 expression level and serum MMP-9 in humans and an association of a SNP in the MMP-9 promoter with coronary artery disease and risk of myocardial infarction lesions
Atherosclerosis MMP3 Myocardial infarction
Association between MMP-9, MMP-3 polymorphisms and risk of myocardial infarction / دراسة الرابطة بين الأشكال المتعددة من مصفوفة ميتالوبروتينيس و و خطر احتشاء عضلة القلب في المرضى المصريين Baher Emil Ibrahim ; Supervised Manal Michel Wilson , Ashraf Wadie Andraos , Nadia Ibrahim Swelem - Cairo : Baher Emil Ibrahim , 2014 - 94 P. : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Myocardial infarction is caused by several inherited and acquired risk factors that predispose to the development of atherosclerotic lesions and plaque rupture.This rupture of an atherosclerotic plaque is a major event in the pathogenesis of an acute myocardial infarction (AMI). MMP-9 (gelatinase B) might play an important role in matrix degradation and the subsequent rupture of the atherosclerotic plaques. A functional single nucleotide polymorphism in the MMP-9 promoter, with a cytosine to thymidine transition at position -1562, was found. The T allele had a higher promoter activity than the C allele, and was associated with an elevation in both the levels of MMP-9 expression level and serum MMP-9 in humans and an association of a SNP in the MMP-9 promoter with coronary artery disease and risk of myocardial infarction lesions
Atherosclerosis MMP3 Myocardial infarction