Markers of myofibroblast progenitor cells as predictors of HCV-induced hepatic fibrosis and carcinogenesis /
Shaimaa Abdelsattar Abbas Hasan
Markers of myofibroblast progenitor cells as predictors of HCV-induced hepatic fibrosis and carcinogenesis / دراسة الدلالات السابحة في الدم و المرتبطة بنزوح الخلايا المكونة للخلايا الليفية العضلية إلى الكبد كمؤشر لحدوث التليف و الأورام السرطانية Shaimaa Abdelsattar Abbas Hasan ; Supervised Inas Ismail Raafat , Mona Mohamed Kamel Zoheiry , Safa Sayed Meshaal - Cairo : Shaimaa Abdelsattar Abbas Hasan , 2014 - 134 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Aim of the work: To analyze the impact of serum biomarkers of EMT on fibrogenic process and progression to tumorogenesis caused by HCV. Results: The serum TGF-Ý1, BMP-7, CTGF and YKL-40 were significantly increased in CHC, LC and HCC cases compared with normal controls (p <0.001). Serum TGF-Ý1/ BMP-7 ratio shows increase from F0 to F4 with no significant difference between LC and HCC. CTGF was significantly high in LC and YKL-40 was significantly high in HCC. Conclusions: Increase of TGF-Ý1/BMP-7 ratio reflects the rate of EMT. In HCV hepatic patients: the simultaneous determination of TGF-Ý1/BMP-7 ratio and of CTGF in serum might provide information on fibrogenic activity, while this ratio in association with YKL-40 can be used for monitoring of the malignant transformation.
EMT Liver fibrosis TGF-Ý1
Markers of myofibroblast progenitor cells as predictors of HCV-induced hepatic fibrosis and carcinogenesis / دراسة الدلالات السابحة في الدم و المرتبطة بنزوح الخلايا المكونة للخلايا الليفية العضلية إلى الكبد كمؤشر لحدوث التليف و الأورام السرطانية Shaimaa Abdelsattar Abbas Hasan ; Supervised Inas Ismail Raafat , Mona Mohamed Kamel Zoheiry , Safa Sayed Meshaal - Cairo : Shaimaa Abdelsattar Abbas Hasan , 2014 - 134 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
Aim of the work: To analyze the impact of serum biomarkers of EMT on fibrogenic process and progression to tumorogenesis caused by HCV. Results: The serum TGF-Ý1, BMP-7, CTGF and YKL-40 were significantly increased in CHC, LC and HCC cases compared with normal controls (p <0.001). Serum TGF-Ý1/ BMP-7 ratio shows increase from F0 to F4 with no significant difference between LC and HCC. CTGF was significantly high in LC and YKL-40 was significantly high in HCC. Conclusions: Increase of TGF-Ý1/BMP-7 ratio reflects the rate of EMT. In HCV hepatic patients: the simultaneous determination of TGF-Ý1/BMP-7 ratio and of CTGF in serum might provide information on fibrogenic activity, while this ratio in association with YKL-40 can be used for monitoring of the malignant transformation.
EMT Liver fibrosis TGF-Ý1