A study of the anti-inflammatory effect of histamine H1 and H4 receptor antagonists on dermatitis in mice /
Ahmed Fathi Mohamed Ahmed Kamal Eldin
A study of the anti-inflammatory effect of histamine H1 and H4 receptor antagonists on dermatitis in mice / المضاد للالتهاب فى التهاب الجلد بالفئران H4 و H1 دراسة لتأثير مضادات مستقبلات الهستامين Ahmed Fathi Mohamed Ahmed Kamal Eldin ; Supervised Mohamed T. Abdelaziz , Fatma A. Elbatrawy , Mohammed F. Elyamany - Cairo : Ahmed Fathi Mohamed Ahmed Kamal Eldin , 2015 - 156 P. : charts , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
The present study aimed to examine the ability of dexamethasone, cetirizine and JNJ7777120 to alleviate FITC - induced inflammation and oxidative stress. Ears of mice treated with the aforementioned agents 20 minutes before and 4 hours after FITC challenge exhibited amelioration of oxidative stress as manifested by decreased TBARS and NOX contents parallel to increased GSH content and SOD activity. Decreased inflammatory biomarkers as manifested by decreased MPO and EPO activities as well as TNF - Ü content. This was associated with a decrease in plasma IgE level and ear IL - 4 content, in addition to improvement of histopathologic insults, decreased ear thickness and reduced bouts of scratching
Dexamethasone Fluorescein isothiocyanate Oxidative stress
A study of the anti-inflammatory effect of histamine H1 and H4 receptor antagonists on dermatitis in mice / المضاد للالتهاب فى التهاب الجلد بالفئران H4 و H1 دراسة لتأثير مضادات مستقبلات الهستامين Ahmed Fathi Mohamed Ahmed Kamal Eldin ; Supervised Mohamed T. Abdelaziz , Fatma A. Elbatrawy , Mohammed F. Elyamany - Cairo : Ahmed Fathi Mohamed Ahmed Kamal Eldin , 2015 - 156 P. : charts , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
The present study aimed to examine the ability of dexamethasone, cetirizine and JNJ7777120 to alleviate FITC - induced inflammation and oxidative stress. Ears of mice treated with the aforementioned agents 20 minutes before and 4 hours after FITC challenge exhibited amelioration of oxidative stress as manifested by decreased TBARS and NOX contents parallel to increased GSH content and SOD activity. Decreased inflammatory biomarkers as manifested by decreased MPO and EPO activities as well as TNF - Ü content. This was associated with a decrease in plasma IgE level and ear IL - 4 content, in addition to improvement of histopathologic insults, decreased ear thickness and reduced bouts of scratching
Dexamethasone Fluorescein isothiocyanate Oxidative stress