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Studying the biostimulatory effect of magnetic nanoparticles on irradiated rats /

Eman Ibraheem Mohammed Sobeh

Studying the biostimulatory effect of magnetic nanoparticles on irradiated rats / دراسة تاثير جسيمات النانو المغناطيسية كمحفز حيوى للفئران المشععة Eman Ibraheem Mohammed Sobeh ; Supervised Souad Elfeky , Rehab Amin , Samia Eldemeryaty Ali - Cairo : Eman Ibraheem Mohammed Sobeh , 2014 - 128 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - National institute of laser Enhanced Sciences - Department of Laser Applications in Environmental Metrology, photochemistry, photo-biology and Agriculture

Ionizing radiation causes serious damage in biological systems. The present study has been carried out to investigate the possible radio-protective effect of Fe₃O₄ nanoparticles (NPs) through the injection before or after whole body gamma irradiation of rats. Fe₃O₄ NPs are known by its low cost and biological safety compared with other chemical radio-protectors. Fe₃O₄ NPs examined at a low concentration dose of 1.5 mg/Kg. Fe₃O₄ NPs was prepared by co-precipitation method and characterized by TEM and XRD. Fifty male albino rats were used per each experiment; they are divided into 5 groups. First, control, second, injected with 1.5mg/Kg Fe₃O₄ NPs twice a week for three weeks. Third, exposed to sublethal dose (5.5 Gy) of whole body gamma irradiation. Fourth, received the same dose of Fe3O4 before exposing to 5.5 Gy radiation. Fifth, received the same dose of Fe₃O₄ after radiation exposure (5.5 Gy) biochemical analysis



Gamma Irradiation Magnetic iron oxide nanoparticles Radio protector