Level of interleukin-37(IL-37) in children with systemic lupus erythematosus and its correlation with disease activity /
Mai Gamal Eldin Sayed Sayed
Level of interleukin-37(IL-37) in children with systemic lupus erythematosus and its correlation with disease activity / نسبة الانترلوكين 37 فى الأطفال المصابين بالذئبة الحمراء وعلاقته بنشاط المرض Mai Gamal Eldin Sayed Sayed ; Supervised Emad Emil Ghobrial , Mervat Mamdouh Ahmed Khorshied , Huda Marzouk Mohammed - Cairo : Mai Gamal Eldin Sayed Sayed , 2015 - 116 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by multiple auto-antibodies against self-directed antigens and multisystemic involvement. The SLE Disease Activity Index (SLEDAI-2K) scoring system evaluates the presence of multiple features of SLE flares at the time of completion or in the previous 10 days. Interleukin 37 (IL-37) is a newly defined member of cytokine family, and it is a key cytokine in regulating inflammation. Objectives: we aimed to detect the level of IL-37 in SLE and correlate it with the activity of disease. Results: Levels of IL-37 in 50 cases with SLE have higher than in 30 controls but without statistically significant difference (P =0.08). Level of IL-37 in active cases with higher than in inactive cases but without statistically significant difference (P =0.58). Level of IL-37 level in mild activity with lower than in moderate or severe active but without statistically significant difference (P =0.23). Level of IL-37 is correlated with delay in diagnosis of disease and SLEDAI-2K score.Conclusion: level of IL-37 is higher in SLE patients than controls and it is higher in active cases than inactive cases. IL-37 is correlated with lag between onset and diagnosis of disease and SLEDAI-2K
Interleukin37 SLEDAI-2K Systemic lupus erythromatosus
Level of interleukin-37(IL-37) in children with systemic lupus erythematosus and its correlation with disease activity / نسبة الانترلوكين 37 فى الأطفال المصابين بالذئبة الحمراء وعلاقته بنشاط المرض Mai Gamal Eldin Sayed Sayed ; Supervised Emad Emil Ghobrial , Mervat Mamdouh Ahmed Khorshied , Huda Marzouk Mohammed - Cairo : Mai Gamal Eldin Sayed Sayed , 2015 - 116 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by multiple auto-antibodies against self-directed antigens and multisystemic involvement. The SLE Disease Activity Index (SLEDAI-2K) scoring system evaluates the presence of multiple features of SLE flares at the time of completion or in the previous 10 days. Interleukin 37 (IL-37) is a newly defined member of cytokine family, and it is a key cytokine in regulating inflammation. Objectives: we aimed to detect the level of IL-37 in SLE and correlate it with the activity of disease. Results: Levels of IL-37 in 50 cases with SLE have higher than in 30 controls but without statistically significant difference (P =0.08). Level of IL-37 in active cases with higher than in inactive cases but without statistically significant difference (P =0.58). Level of IL-37 level in mild activity with lower than in moderate or severe active but without statistically significant difference (P =0.23). Level of IL-37 is correlated with delay in diagnosis of disease and SLEDAI-2K score.Conclusion: level of IL-37 is higher in SLE patients than controls and it is higher in active cases than inactive cases. IL-37 is correlated with lag between onset and diagnosis of disease and SLEDAI-2K
Interleukin37 SLEDAI-2K Systemic lupus erythromatosus