Serum leptin, pregnancy associated plasma protein A. and high sensitivity c reactive protein levels as indicators of extent and severity of coronary artery disease in patients with acute coronary syndrome /
Ahmed Mohamed Abdelaleem Elbadawy
Serum leptin, pregnancy associated plasma protein A. and high sensitivity c reactive protein levels as indicators of extent and severity of coronary artery disease in patients with acute coronary syndrome / نسبة قياس الليبتين و بروتين أ المرتبط بالحمل و البروتين سي التفاعلي شديد الحساسية كدلالات على امتداد و شدة قصور الشرايين التاجية في مرضى قصور الشرايين التاجية Ahmed Mohamed Abdelaleem Elbadawy ; Supervised Tarek Elgouhary , Amaal Rizk , Mohamed Fawzy - Cairo : Ahmed Mohamed Abdelaleem Elbadawy , 2015 - 172 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine
Multifactorial etiology of coronary artery disease (CAD) has been established in the recent studies. Extensive research is now underway to understand the mechanisms responsible for plaque vulnerability. The identification of a novel biomarker that will help in the assessment of plaque status is urgently needed for the purpose of patient stratification and prognostication. The aim of the present study was to evaluate leptin, pregnancy-associated plasma protein A (PAPP-A) and high sensitive C-reactive protein (hs-CRP) levels in patients with acute coronary syndrome and to assess their diagnostic efficacy in the identification of vulnerable plaques. Methods: The study group comprised 20 patients who had chest pain along with ECG changes (ST elevation, ST depression, T inversion) and raised cardiac enzyme levels. Twenty patients with chest pain and ECG changes but with normal cardiac enzyme profiles were included in the control group. Lipid profiles, and leptin, PAPP-A and CRP levels were assessed in these two groups. Box-Plot and Receiver operating characteristics (ROC) curves were plotted to determine the utility of the parameters under study as markers of plaque vulnerability. Results: Significantly higher levels of serum, leptin, PAPP-A and high-sensitivity CRP (hs-CRP) were observed in group 2 than in group 1. A positive correlation was observed between CRP and PAPP-A levels as well as CRP and leptin concentrations. ROC curve analysis revealed better efficacy of PAPP-A level over hs-CRP level in their ability to detect unstable plaques with areas under the curve of 0.919 for PAPP A versus 0.774 for hs-CRP, respectively
hs-CRP Leptin PAPP-A
Serum leptin, pregnancy associated plasma protein A. and high sensitivity c reactive protein levels as indicators of extent and severity of coronary artery disease in patients with acute coronary syndrome / نسبة قياس الليبتين و بروتين أ المرتبط بالحمل و البروتين سي التفاعلي شديد الحساسية كدلالات على امتداد و شدة قصور الشرايين التاجية في مرضى قصور الشرايين التاجية Ahmed Mohamed Abdelaleem Elbadawy ; Supervised Tarek Elgouhary , Amaal Rizk , Mohamed Fawzy - Cairo : Ahmed Mohamed Abdelaleem Elbadawy , 2015 - 172 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Critical Care Medicine
Multifactorial etiology of coronary artery disease (CAD) has been established in the recent studies. Extensive research is now underway to understand the mechanisms responsible for plaque vulnerability. The identification of a novel biomarker that will help in the assessment of plaque status is urgently needed for the purpose of patient stratification and prognostication. The aim of the present study was to evaluate leptin, pregnancy-associated plasma protein A (PAPP-A) and high sensitive C-reactive protein (hs-CRP) levels in patients with acute coronary syndrome and to assess their diagnostic efficacy in the identification of vulnerable plaques. Methods: The study group comprised 20 patients who had chest pain along with ECG changes (ST elevation, ST depression, T inversion) and raised cardiac enzyme levels. Twenty patients with chest pain and ECG changes but with normal cardiac enzyme profiles were included in the control group. Lipid profiles, and leptin, PAPP-A and CRP levels were assessed in these two groups. Box-Plot and Receiver operating characteristics (ROC) curves were plotted to determine the utility of the parameters under study as markers of plaque vulnerability. Results: Significantly higher levels of serum, leptin, PAPP-A and high-sensitivity CRP (hs-CRP) were observed in group 2 than in group 1. A positive correlation was observed between CRP and PAPP-A levels as well as CRP and leptin concentrations. ROC curve analysis revealed better efficacy of PAPP-A level over hs-CRP level in their ability to detect unstable plaques with areas under the curve of 0.919 for PAPP A versus 0.774 for hs-CRP, respectively
hs-CRP Leptin PAPP-A