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A comparative study between standard and transepithelial corneal collagen crosslinking in keratoconus /

Ahmed Mohamed Elshewy

A comparative study between standard and transepithelial corneal collagen crosslinking in keratoconus / دراسه مقارنه بين تشابك الكولاجين للقرنيه التقليدى و عبر الخلايا الطلائيه فى القرنيه المخروطيه Ahmed Mohamed Elshewy ; Supervised Riad Bahey Eldin Shalash , Hazem Mohamed Yassin , Mohamed Ahmed Awadalla - Cairo : Ahmed Mohamed Elshewy , 2015 - 117 P. : facsimiles ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

To compare safety and efficacy of transepithelial (epi - on) corneal collagen crosslinking as opposed to standard (epi-off) corneal collagen crosslinking, in the management of keratoconus. Prospective, interventional, non-randomized, non controlled study. 40 keratoconus eyes divided in 2 groups: 20 eyes in Group (1) received standard (epi - off) crosslinking and 20 eyes in Group 2 received transepithelial (epi - on) crosslinking. All patients were evaluated regarding best spectacle corrected visual acuity (BSCVA), corneal maximum keratometric value (Kmax), central corneal thickness (CCT), corneal hysteresis (CH) and corneal resistance factor (CRF). These aspects were evaluated preoperatively and postoperatively after 3, 6 and 12 months. Regarding BSCVA, standard CXL group showed insignificantly increase (improvement) after 1 year, while Transepithelial CXL group showed significantly decrease (worsening). Regarding Kmax, both groups showed flattening, which was statistically significant in Standard CXL group and insignificant in Transepithelial CXL group. Regarding CCT, both groups showed statistically significant thinning. Regarding CH and CRF, there was decrease in values in both groups



Corneal collagen crosslinking Keratoconus Transepithelial