Teratogenic effects of bronchodilators drug on the pregnant female of albino rats and their offsprings /
Heba Ali Abdelrahman Shalabi
Teratogenic effects of bronchodilators drug on the pregnant female of albino rats and their offsprings / التأثيرات المشوهة لأدوية موسعات الشعب على إناث الفئران الحوامل ونسلها Heba Ali Abdelrahman Shalabi ; Supervised Abdelwahab A. Elghareeb , Sayed Fahim Tahaa , Alaa A. Shamkh - Cairo : Heba Ali Abdelrahman Shalabi , 2015 - 260 Leaves : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology
The present study aimed to evaluate the teratogenic effects of the mucolytic and broncholytic drug (Mucophylline) is daily oral administered to the pregnant albino rats. The pregnant animals treated during the gestational period (5th 19th day of gestation) with doses 30.83 mg/Kg and 66.61 mg/Kg (human equivalent dose). On the 20th day of gestation, the animals were sacrificed and the numbers of implanation sites, resorbed and live fetuses were counted. The placental weight, fetal weight, length and tail length were recorded. The external morphology and skeletal malformations, histological studies of placenta, brain, liver and kidney of mother and fetus were evaluated. Also the oxidative stress markers were evaluated. Results showed decreased weight gain, fetal growth retardation during gestation period was dose dependent. Hematoma and anomalies of limbs were detected morphologically in the fetuses of maternally treated groups. Fetal skeletal abnormalities included lack of bones ossification and bent ribs.
Pregnant albino rats Skeletal malformation Teratogenecity
Teratogenic effects of bronchodilators drug on the pregnant female of albino rats and their offsprings / التأثيرات المشوهة لأدوية موسعات الشعب على إناث الفئران الحوامل ونسلها Heba Ali Abdelrahman Shalabi ; Supervised Abdelwahab A. Elghareeb , Sayed Fahim Tahaa , Alaa A. Shamkh - Cairo : Heba Ali Abdelrahman Shalabi , 2015 - 260 Leaves : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology
The present study aimed to evaluate the teratogenic effects of the mucolytic and broncholytic drug (Mucophylline) is daily oral administered to the pregnant albino rats. The pregnant animals treated during the gestational period (5th 19th day of gestation) with doses 30.83 mg/Kg and 66.61 mg/Kg (human equivalent dose). On the 20th day of gestation, the animals were sacrificed and the numbers of implanation sites, resorbed and live fetuses were counted. The placental weight, fetal weight, length and tail length were recorded. The external morphology and skeletal malformations, histological studies of placenta, brain, liver and kidney of mother and fetus were evaluated. Also the oxidative stress markers were evaluated. Results showed decreased weight gain, fetal growth retardation during gestation period was dose dependent. Hematoma and anomalies of limbs were detected morphologically in the fetuses of maternally treated groups. Fetal skeletal abnormalities included lack of bones ossification and bent ribs.
Pregnant albino rats Skeletal malformation Teratogenecity