Impact of augmented renal clearnce on enoxaparin therapy in critically ill pateints /
Dina Atteya Mohamed Atteya
Impact of augmented renal clearnce on enoxaparin therapy in critically ill pateints / تأثير زيادة التنقية الكلوية على علاج بالإينوكسبارين في مرضى الحالات الحرجة Dina Atteya Mohamed Atteya ; Supervised Hala Ezzat Mohamed Abdelnaeem , Mona Hossam Eldin Abdelhameed , Ahmed Mohamed Ibrahim Hasanin - Cairo : Dina Atteya Mohamed Atteya , 2015 - 58 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia
Fifty critically ill patients receiving enoxaparin prophylactic dose (40mg/day) were included in the study. Creatinine clearance was measured and patients were divided into two groups: normal kidney function group (group C) and augmented renal clearance group (group A). serum anti-factor Xa was measured at baseline, four hours, 12 hours, and 24 hours. Both groups were compared regarding demographic data, severity scores, kidney function, and anti-factor Xa activity.Results Twenty patients (40%) showed ARC and thirty patients (60%) showed normal kidney function. Creatinine clearance was 214±6 in group A versus 112±11 in group C (P=0.001). Serum anti-factor Xa levels was similar in the two groups after four hours (0.2±0.07 Vs 0.2±0.05, P=1). Serum anti-Xa levels were significantly lower in group A compared to group C at 12 and 24 hours (0.06±0.03 Vs 0.1±0.04, P=0.004), (0.01±0.01 Vs 0.05±0.01, P=0.001) respectively.Conclusion ARC patients showed short activity of enoxaparin. This finding draws the attention towards dose adjustment in this type of patients
Anaesthesia Critically ill Enoxaparin therapy
Impact of augmented renal clearnce on enoxaparin therapy in critically ill pateints / تأثير زيادة التنقية الكلوية على علاج بالإينوكسبارين في مرضى الحالات الحرجة Dina Atteya Mohamed Atteya ; Supervised Hala Ezzat Mohamed Abdelnaeem , Mona Hossam Eldin Abdelhameed , Ahmed Mohamed Ibrahim Hasanin - Cairo : Dina Atteya Mohamed Atteya , 2015 - 58 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia
Fifty critically ill patients receiving enoxaparin prophylactic dose (40mg/day) were included in the study. Creatinine clearance was measured and patients were divided into two groups: normal kidney function group (group C) and augmented renal clearance group (group A). serum anti-factor Xa was measured at baseline, four hours, 12 hours, and 24 hours. Both groups were compared regarding demographic data, severity scores, kidney function, and anti-factor Xa activity.Results Twenty patients (40%) showed ARC and thirty patients (60%) showed normal kidney function. Creatinine clearance was 214±6 in group A versus 112±11 in group C (P=0.001). Serum anti-factor Xa levels was similar in the two groups after four hours (0.2±0.07 Vs 0.2±0.05, P=1). Serum anti-Xa levels were significantly lower in group A compared to group C at 12 and 24 hours (0.06±0.03 Vs 0.1±0.04, P=0.004), (0.01±0.01 Vs 0.05±0.01, P=0.001) respectively.Conclusion ARC patients showed short activity of enoxaparin. This finding draws the attention towards dose adjustment in this type of patients
Anaesthesia Critically ill Enoxaparin therapy