Histological study on the possible protective effect of thyroid hormone on hepatic ischemia reperfusion injury in male rats /
Hanan Abdalla Hassan Bastawy
Histological study on the possible protective effect of thyroid hormone on hepatic ischemia reperfusion injury in male rats / دراسة هستولوجية وهستوكيميائية مناعية على التأثيرالوقائي المحتمل لهرمون الغدة الدرقية في الأصابة التى يسببها إنقطاع الدم ثم إعادة ضخه فى كبد الجرذان Hanan Abdalla Hassan Bastawy ; Supervised Mohammed Ahmed Abdalhafez , Mira Farouk Youssef , Dalia Ibrahim Ismail - Cairo : Hanan Abdalla Hassan Bastawy , 2016 - 121 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology
This study aimed at evaluating the effects of thyroid hormone (TH) on Ischemia reperfusion injury (IRI) in rat liver. Results: group II, showed no significant difference in the mean serum AST & ALT levels compared to the control rats. H&E sections revealed similar histological architecture of the liver parynchema as in control group. The statistical difference of the optical density of PAS and the mean area % of CD68 & iNOS immunoreactivity was non significant as compared with the control.. Group III showed significant increased in the mean serum AST & ALT levels compared to the control group. The H&E stained liver sections revealed disorganization, degeneration and necrosis of the hepatocytes with significant decrease in of the optical density of PAS and significant increase in the mean area % of CD68 & iNOS immunoreactivity compared to the control. Group VI showed significant decrease in the mean serum AST & ALT levels with decrease in the histological alterations caused by IRI. There was significance increase in the optical density of PAS reaction and significance decrease in the mean area % of CD68 and iNOS immunoreactivity when compared to the IRI group. Conclusion: TH have protective effect against hepatic IRI
CD68 Ischemia reperfusion injury Thyroid hormone
Histological study on the possible protective effect of thyroid hormone on hepatic ischemia reperfusion injury in male rats / دراسة هستولوجية وهستوكيميائية مناعية على التأثيرالوقائي المحتمل لهرمون الغدة الدرقية في الأصابة التى يسببها إنقطاع الدم ثم إعادة ضخه فى كبد الجرذان Hanan Abdalla Hassan Bastawy ; Supervised Mohammed Ahmed Abdalhafez , Mira Farouk Youssef , Dalia Ibrahim Ismail - Cairo : Hanan Abdalla Hassan Bastawy , 2016 - 121 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology
This study aimed at evaluating the effects of thyroid hormone (TH) on Ischemia reperfusion injury (IRI) in rat liver. Results: group II, showed no significant difference in the mean serum AST & ALT levels compared to the control rats. H&E sections revealed similar histological architecture of the liver parynchema as in control group. The statistical difference of the optical density of PAS and the mean area % of CD68 & iNOS immunoreactivity was non significant as compared with the control.. Group III showed significant increased in the mean serum AST & ALT levels compared to the control group. The H&E stained liver sections revealed disorganization, degeneration and necrosis of the hepatocytes with significant decrease in of the optical density of PAS and significant increase in the mean area % of CD68 & iNOS immunoreactivity compared to the control. Group VI showed significant decrease in the mean serum AST & ALT levels with decrease in the histological alterations caused by IRI. There was significance increase in the optical density of PAS reaction and significance decrease in the mean area % of CD68 and iNOS immunoreactivity when compared to the IRI group. Conclusion: TH have protective effect against hepatic IRI
CD68 Ischemia reperfusion injury Thyroid hormone