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Evaluation of antidiabetic effect of berberine in type 2 diabetic rats models /

Marwa Mohamed Abdelrahman

Evaluation of antidiabetic effect of berberine in type 2 diabetic rats models / تقييم التأثيرات المضادة للسكرى للبربرين على الجرزان المصابة بداء السكرى النوع الثانى Marwa Mohamed Abdelrahman ; Supervised Hassan Mohamed Eissa , Nermeen Abdallah Bastawy , Ayman Mahmoud Moawad - Cairo : Marwa Mohamed Abdelrahman , 2016 - 153 P. : charts ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology

Berberine exists in a number of medicinal plants and displays many pharmacological effects on type 2 diabetes mellitus. The study aimed to determine the hypoglycemic effects of berberine in rats with type 2 diabetes, on inflammatory biomarkers, insulin, adiponectin, lipid profile, liver oxidative stress biomarkers, mRNA expression levels of PPARÞ and resistin. Diabetes was induced by feeding rats with high fat diet for 4 weeks followed by injection of STZ, Oral doses of 50 and 100 mg/kgberberine were daily given for 4 weeks after diabetes induction



Berberine Insulin resistance Type 2 diabetes