Evaluation of the effect of metronidazole loaded polylactic co glycolic acid nanoparticles polylactic co glycolic acid nanoparticles only on gingival bleeding index with open flap debridement in patients with chronic periodontitis : A split mouth randomized clinical trial /
Lubna Ehab Elshalakany
Evaluation of the effect of metronidazole loaded polylactic co glycolic acid nanoparticles polylactic co glycolic acid nanoparticles only on gingival bleeding index with open flap debridement in patients with chronic periodontitis : A split mouth randomized clinical trial / لتقييم لاستخدام المترونيدازول المحمل على جزيئات النانو لحمض اللبنيك المتعدد مشارك مع حمض الجليكوليك المتعدد و جزيئات النانو لحمض اللبنيك المتعدد مشارك مع حمض الجليكوليك المتعدد فقط مع جراحة سديلية مفتوحة كمساعد فى علاج التهابات الانسجة حول السنية المزمنة : تقسيم الفم فى تجربه سريرية عشوائية Lubna Ehab Elshalakany ; Supervised Manal Hosny Mostafa , Maha Mohammad Sallam , Enji Ahmed - Cairo : Lubna Ehab Elshalakany , 2016 - 119 P. : charts , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology
The primary goal of periodontal therapy is the alteration of subgingival biofilms present on periodontally diseased sites that could be associated with the progressive destruction of the supportive periodontal tissues. Studies evaluating the effect of locally delivered antimicrobials (LDAs) as an adjunctive therapy to periodontal surgery revealed evidence of improved clinical outcomes in terms of the greater PD reduction and/or clinical attachment gain compared to periodontal surgery alone. Therefore, the aim of the present to evaluate the effect of metronidazole-loaded PLGA nanoparticles combined with open flap debridement versus PLGA nanoparticles combined with open flap debridement on gingival inflammation in patients with chronic periodontitis. Split mouth design was applied where each patient presented 2 contalateral sites with PD 5mm and these sites were randomly assigned to 1 of 2 groups as follows: Group I received OFD with local delivery of 2 ml of metronidazole loaded PLGA nanoparticles gel using a plastic syringe where 1 ml was delivered after debridement and the other 1 ml after suturing. Group II received OFD with local delivery of 2 ml PLGA nanoparticles gel using a plastic syringe where 1 ml was delivered after debridement and the other 1 ml after suturing
Gingival bleeding index Metronidazole loaded polylactic co glycolic acid nanoparticles Patients with chronic periodontitis
Evaluation of the effect of metronidazole loaded polylactic co glycolic acid nanoparticles polylactic co glycolic acid nanoparticles only on gingival bleeding index with open flap debridement in patients with chronic periodontitis : A split mouth randomized clinical trial / لتقييم لاستخدام المترونيدازول المحمل على جزيئات النانو لحمض اللبنيك المتعدد مشارك مع حمض الجليكوليك المتعدد و جزيئات النانو لحمض اللبنيك المتعدد مشارك مع حمض الجليكوليك المتعدد فقط مع جراحة سديلية مفتوحة كمساعد فى علاج التهابات الانسجة حول السنية المزمنة : تقسيم الفم فى تجربه سريرية عشوائية Lubna Ehab Elshalakany ; Supervised Manal Hosny Mostafa , Maha Mohammad Sallam , Enji Ahmed - Cairo : Lubna Ehab Elshalakany , 2016 - 119 P. : charts , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology
The primary goal of periodontal therapy is the alteration of subgingival biofilms present on periodontally diseased sites that could be associated with the progressive destruction of the supportive periodontal tissues. Studies evaluating the effect of locally delivered antimicrobials (LDAs) as an adjunctive therapy to periodontal surgery revealed evidence of improved clinical outcomes in terms of the greater PD reduction and/or clinical attachment gain compared to periodontal surgery alone. Therefore, the aim of the present to evaluate the effect of metronidazole-loaded PLGA nanoparticles combined with open flap debridement versus PLGA nanoparticles combined with open flap debridement on gingival inflammation in patients with chronic periodontitis. Split mouth design was applied where each patient presented 2 contalateral sites with PD 5mm and these sites were randomly assigned to 1 of 2 groups as follows: Group I received OFD with local delivery of 2 ml of metronidazole loaded PLGA nanoparticles gel using a plastic syringe where 1 ml was delivered after debridement and the other 1 ml after suturing. Group II received OFD with local delivery of 2 ml PLGA nanoparticles gel using a plastic syringe where 1 ml was delivered after debridement and the other 1 ml after suturing
Gingival bleeding index Metronidazole loaded polylactic co glycolic acid nanoparticles Patients with chronic periodontitis