Epigenetics of the Epigenetics : Hypermethylation of microRNA let-7a-3 gene represses the primary and mature let-7a with an inverse correlation to IGF-II mRNA in HCV-induced hepatocellular carcinoma /
Amr Adel Waly
Epigenetics of the Epigenetics : Hypermethylation of microRNA let-7a-3 gene represses the primary and mature let-7a with an inverse correlation to IGF-II mRNA in HCV-induced hepatocellular carcinoma / Amr Adel Waly ; Supervised Ahmed Ihab Abdelaziz , Hand Mohamed Eltayebi - Cairo : Amr Adel Waly , 2013 - 107 Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - Cairo University - Garman University - Faculty of Postgraduate Studies and Scientific Research- Department of Molecular Pharmacology
Ongoing research has been focusing on the impact of the interplay between epigenetic mechanisms on malignant transformation. This work investigated the crosstalk between two of the epigenetic mechanisms: DNA methylation and microRNAs, in hepatocellular carcinoma (HCC). MicroRNA let-7a is a member of the arechetypal let-7a miRNA gene family. Owing to its know tumor suppressor activity, aberrant expression of microRNA let-7a was found to deregulate ~200 gene involved in cell proliferation, differentiation and adhesion.
Hepatocellular carcinoma (HCC) IGF-II mRNA microRNA let-7a-3 gene
Epigenetics of the Epigenetics : Hypermethylation of microRNA let-7a-3 gene represses the primary and mature let-7a with an inverse correlation to IGF-II mRNA in HCV-induced hepatocellular carcinoma / Amr Adel Waly ; Supervised Ahmed Ihab Abdelaziz , Hand Mohamed Eltayebi - Cairo : Amr Adel Waly , 2013 - 107 Leaves : charts , facsimiles ; 30cm
Thesis (M.Sc.) - Cairo University - Garman University - Faculty of Postgraduate Studies and Scientific Research- Department of Molecular Pharmacology
Ongoing research has been focusing on the impact of the interplay between epigenetic mechanisms on malignant transformation. This work investigated the crosstalk between two of the epigenetic mechanisms: DNA methylation and microRNAs, in hepatocellular carcinoma (HCC). MicroRNA let-7a is a member of the arechetypal let-7a miRNA gene family. Owing to its know tumor suppressor activity, aberrant expression of microRNA let-7a was found to deregulate ~200 gene involved in cell proliferation, differentiation and adhesion.
Hepatocellular carcinoma (HCC) IGF-II mRNA microRNA let-7a-3 gene