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Design and synthesis of novel quinaziline derivatives as potential dual EGFR/NF- кB inhibitors /

Sarah Sameh Fayez Mohamed Darwish

Design and synthesis of novel quinaziline derivatives as potential dual EGFR/NF- кB inhibitors / Sarah Sameh Fayez Mohamed Darwish ; Supervised Ashraf H. Abadi , Mostafa Hamed - Cairo : Sarah Sameh Fayez Mohamed Darwish , 2014 - 88 Leaves : charts , facsimiles ; 30cm

Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

The epidermal growth factor receptor (EGFR) is a membrane bound tyrosine kinase involved in callular signaling transduction pathways that control vital functions such as proliferation, differetiation and apoptosis . the overexpression of EGFR was observed in several types of cancers such as the non-samall cell lung carcinoma (NSCLC) which is among the most common causes of cancer-related death.

Potential dual EGFR/NF- кB inhibitors The epidermal growth factor receptor (EGFR) The non-samall cell lung carcinoma (NSCLC)