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Reduction of hepatitis C viral replication through targeting HCV-genotype 4p7 Ion channal by MicroRNA-29a /

Radwa Ayman Salah Helmy

Reduction of hepatitis C viral replication through targeting HCV-genotype 4p7 Ion channal by MicroRNA-29a / Radwa Ayman Salah Helmy ; Supervised Ahmed Ihab Abdelaziz - Cairo : Radwa Ayman Salah Helmy , 2013 - 105 Leaves : charts ; 30cm

Thesis (M.Sc.) - Garman University - Faculty of Postgraduate Studies and Scientific Research - Department of Molecular Pharmacology

Hepatitis C virus infection (HCV) is a global health crisis, characterized by a virusmediated suppression of the host immune response. It is considered a leading cause of chronic liver disease worldwide. Egypt is considered to have the highest prevalence of HCV globally (17%), where the majority of cases are infected with the " difficutlt-to-treat" genotype 4.p7 is viral protein that acts as an ion channel and has a crucial role in HCV life cycle, rendering it an attractive therapeutic target.

HCV-genotype 4p7 Ion channal Hepatitis C virus infection (HCV) MicroRNA-29a