Brain targeting for a central nervous system acting drug /
Fatma Elzahraa Abdelrahman Mohammed
Brain targeting for a central nervous system acting drug / التهديف الدماغى لعقار يعمل على الجهاز العصبى المركزى Fatma Elzahraa Abdelrahman Mohammed ; Supervised Magdy Ibrahim , Ibrahim Elsayed Mohamed Hassan , Mary Kamal Gad - Cairo : Fatma Elzahraa Abdelrahman Mohammed , 2017 - 149 P. : charts , facsimiles , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
The aim of this study was to enhance the risperidone delivery to the brain through the transnasal route via optimization of cubosomal gel and spanlastics. The work in this thesis is divided into: Chapter I: Formulation and evaluation of intranasal risperidone cubosomes. Chapter II: Formulation and evaluation of intranasal risperidone spanlastics. Chapter I: Formulation and evaluation of intranasal risperidone cubosomes: Risperidone cubosomal dispersions were prepared by melt dispersion-emulsification technique. The prepared formulae were characterized for their particle size, zeta potential, polydispersity index and entrapment efficiency. In vitro drug release was determined for optimized cubosomal dispersion. Also, cubosomal gel formulae were prepared by the same technique using mucoadhesive polymers (gellan gum and polyethylene oxide) dissolved in aqueous phase before mixing with glyceryl monooleate (GMO). Finally, optimized cubosomal dispersion (OCD) and gel (OCG) were evaluated for previously mentioned parameters in addition to in vivo evaluation. Chapter II: Formulation and evaluation of intranasal risperidone spanlastics: Risperidone intranasal spanlastics formulae were prepared using the ethanol injection method. The prepared formulae were characterized by testing their particle size, polydispersity index, zeta potential, entrapment efficiency, then the selected optimized formula was subjected to in vitro dissolution study, transmission electron microscopy, ex vivo evaluation and in vivo biodistribution study
Brain targeting Central nervous system Intranasal risperidone cubosomes
Brain targeting for a central nervous system acting drug / التهديف الدماغى لعقار يعمل على الجهاز العصبى المركزى Fatma Elzahraa Abdelrahman Mohammed ; Supervised Magdy Ibrahim , Ibrahim Elsayed Mohamed Hassan , Mary Kamal Gad - Cairo : Fatma Elzahraa Abdelrahman Mohammed , 2017 - 149 P. : charts , facsimiles , photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
The aim of this study was to enhance the risperidone delivery to the brain through the transnasal route via optimization of cubosomal gel and spanlastics. The work in this thesis is divided into: Chapter I: Formulation and evaluation of intranasal risperidone cubosomes. Chapter II: Formulation and evaluation of intranasal risperidone spanlastics. Chapter I: Formulation and evaluation of intranasal risperidone cubosomes: Risperidone cubosomal dispersions were prepared by melt dispersion-emulsification technique. The prepared formulae were characterized for their particle size, zeta potential, polydispersity index and entrapment efficiency. In vitro drug release was determined for optimized cubosomal dispersion. Also, cubosomal gel formulae were prepared by the same technique using mucoadhesive polymers (gellan gum and polyethylene oxide) dissolved in aqueous phase before mixing with glyceryl monooleate (GMO). Finally, optimized cubosomal dispersion (OCD) and gel (OCG) were evaluated for previously mentioned parameters in addition to in vivo evaluation. Chapter II: Formulation and evaluation of intranasal risperidone spanlastics: Risperidone intranasal spanlastics formulae were prepared using the ethanol injection method. The prepared formulae were characterized by testing their particle size, polydispersity index, zeta potential, entrapment efficiency, then the selected optimized formula was subjected to in vitro dissolution study, transmission electron microscopy, ex vivo evaluation and in vivo biodistribution study
Brain targeting Central nervous system Intranasal risperidone cubosomes