Modulation of intestinal gut barrier permeability by dipeptidyl peptidase IV inhibition in a model of rat septicemia /
Doaa Abdallah Zaky
Modulation of intestinal gut barrier permeability by dipeptidyl peptidase IV inhibition in a model of rat septicemia / تعديل نفاذية الحاجز المعوي بتثبيط ثنائي ببتيديل ببتيداز 4 في نموذج لتسمم الدم في الجرذان Doaa Abdallah Zaky B.Pharm ; Supervised Dalaal Moustafa Abdallah , Noha Nagah Nassar , Muhammad Yusuf Alshorbagy - Cairo : Doaa Abdallah Zaky B.Pharm , 2017 - 158 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy- Department of Pharmacology and Toxicology
BThe preferential role of the underlying PI3K/Akt (PKB) axis in triggering enterocytic proliferation/differentiation signaling and AJ assembly is still controversial. The involvement of CD26/DPP-IV in obstructive jaundice (OJ)-induced sepsis has not been yet reported VLD3/10/30 dose dependently modulated CD26/DPP-IV, GLP-1, IGF-1, PI3K, pS473-Akt, pS9-GSK-3Ý, pS133-CREB, and CD1. VLD3/10 increased E-cadherin and NPSH, however, they reduced pY654-Ý-catenin, portal and aortic endotoxin, NF-mB, TNF-Ü, MPO, TBARS, subepithelial/pericryptal and submucosal collagen deposition as well as vimentin immunoreactivity, effects that were quite opposed with VLD30.
Adherens junctions Oxidative stress Vildagliptin
Modulation of intestinal gut barrier permeability by dipeptidyl peptidase IV inhibition in a model of rat septicemia / تعديل نفاذية الحاجز المعوي بتثبيط ثنائي ببتيديل ببتيداز 4 في نموذج لتسمم الدم في الجرذان Doaa Abdallah Zaky B.Pharm ; Supervised Dalaal Moustafa Abdallah , Noha Nagah Nassar , Muhammad Yusuf Alshorbagy - Cairo : Doaa Abdallah Zaky B.Pharm , 2017 - 158 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy- Department of Pharmacology and Toxicology
BThe preferential role of the underlying PI3K/Akt (PKB) axis in triggering enterocytic proliferation/differentiation signaling and AJ assembly is still controversial. The involvement of CD26/DPP-IV in obstructive jaundice (OJ)-induced sepsis has not been yet reported VLD3/10/30 dose dependently modulated CD26/DPP-IV, GLP-1, IGF-1, PI3K, pS473-Akt, pS9-GSK-3Ý, pS133-CREB, and CD1. VLD3/10 increased E-cadherin and NPSH, however, they reduced pY654-Ý-catenin, portal and aortic endotoxin, NF-mB, TNF-Ü, MPO, TBARS, subepithelial/pericryptal and submucosal collagen deposition as well as vimentin immunoreactivity, effects that were quite opposed with VLD30.
Adherens junctions Oxidative stress Vildagliptin