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Study of nigella sativa oil versus topical corticosteroid in the management of oral lichen planus : A clinical study /

Hend Abdelghany Mohammad Hassan

Study of nigella sativa oil versus topical corticosteroid in the management of oral lichen planus : A clinical study / فعالية زيت حبة البركة الموضعي بالمقارنة مع الاستيرويد الموضعي لعلاج مرض الحزاز المنبسط الفمىّ : دراسة اكلينيكية Hend Abdelghany Mohammad Hassan ; Supervised Atef Elshahat Attia , Manal Mohammad Hosny , Ahmed A. Hussein - Cairo : Hend Abdelghany Mohammad Hassan , 2011 - 152 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Aim: To compare the efficacy of Nigella sativa (N.sativa) oil (gel preparation 1% concentration) lesions versus triamcinolone acetonide 0.1% in orabase on the signs and symptoms of oral lichen planus (OLP). Subjects and method: A case control study of 20 patients diagnosed as having OLP. 10 patients applied N.sativa oil (1% gel preparation) and 10 patients applied Triamcinolone acetonide 0.1% in orabase topically ; both treatments were applied 4 times daily for 4 weeks and follow up was done clinically 2 and 4weeks post treatment using the numerical rating scale (NRS), the change in symptom scale (CSS) and the modified oral mucositis index (MOMI). Results: There was significant improvement in clinical signs and symptoms 2 and 4 weeks after treatment in both groups, there was no statistical significant difference in mean% reduction in all of the measures of symptoms and signs scale between the two groups. Conclusion: The topical application of the gel preparation of N.sativa oil (1%concentration) produced a comparable improvement in signs and symptoms of OLP to topical application of triamcinolone acetonide 0.1%. In addition; it can induce complete resolution of symptoms



N.sativa OLP T-lymphocytes